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Human Drugs

FDA Obesity/Overweight Drug Development Guide

FDA publishes a draft guidance with recommendations on clinical trials for drugs and biologics to treat obesity and overweight.

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Off-Label Communications Q&A Guide

FDA issues a guidance finalizing a 2023 draft document on communicating scientific information on unapproved uses of approved or cleared medical produ...

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Human Drugs

Rybrevant/Lazcluze Cancer Study Positive: J&J

Johnson & Johnson says its Phase 3 MARIPOSA study showed that its Rybrevant (amivantamab-vmjw) plus Lazcluze (lazertinib) had a statistically signific...

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Federal Register

Jiao Debarment Notice Corrected

Federal Register notice: FDA corrects a 12/5/2024 debarment notice against Yong Sheng Jiao (also known as Yongsheng Jiao and Wilson Jiao).

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Human Drugs

2 ALS Drugs Miss Endpoints

Denali Therapeutics and Calico Life Sciences say their two eukaryotic initiation factor 2B activator drugs each failed to meet primary and secondary e...

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Medical Devices

Lifecycle Recommendations for AI-Enabled Devices

FDA publishes a draft guidance with recommendations on lifecycle management and marketing submissions for AI-enabled medical device software functions...

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Sex Differences in Clinical Evaluations of Products

FDA publishes a draft guidance intended to improve the representation of females in medical product clinical trials.

Biologics

RSV Vaccines Get Guillain-Barr Warning

FDA requires safety labeling changes about Guillain-Barr syndrome risks for Pfizers Abrysvo (respiratory syncytial virus vaccine) and GlaxoSmithKline ...

Human Drugs

Ionis Spinraza Approved by FDA for SMA

FDA approves Ionis Spinraza as the first drug approved to treat children and adults with spinal muscular atrophy.

Human Drugs

FDA OKs Galderma Dermatitis Drug Nemluvio

FDA approves Galdermas Nemluvio to treat some dermatitis patients aged 12 and older.