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FDA grants interchangeability designations to Celltrion’s denosumab biosimilars, Stoboclo (denosumab-bmwo) and Osenvelt (denosumab-bmwo), making them fully substitutable at the pharmacy level for Amgen’s reference biologics Prolia and Xgeva, respectively.

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FDA issues an updated safety communication confirming long-term post-approval data showing that the Hintermann Series H3 Total Ankle Replacement system continues to demonstrate a higher-than-expected risk of device failure.

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Interchangeability Status on Celltrion Biosimilars

FDA grants interchangeability designations to Celltrion’s denosumab biosimilars, Stoboclo (denosumab-bmwo) and Osenvelt (denosumab-bmwo), making them fully substitutable at the pharmacy level for Amgen’s reference biologics Prolia and Xgeva, respectively.

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Safety Data Update on Hintermann Ankle Device

FDA issues an updated safety communication confirming long-term post-approval data showing that the Hintermann Series H3 Total Ankle Replacement system continues to demonstrate a higher-than-expected risk of device failure.

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Lilly Hopeful Obesity Pill Accepted in Voucher Program

Eli Lilly says its investigational weight-loss pill met most criteria for FDA’s new national priority voucher program and could be a potential candidate for a speedy review.

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J&J Seeks Stelara Expanded Use

Johnson & Johnson files a supplemental BLA seeking to expand the use of its biologic therapy Stelara (ustekinumab) to treat children aged two years and older with moderately to severely active ulcerative colitis.

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Animal Drugs

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10/9 Vaccines Panel to Recommend Flu Strain Selection

FDA schedules a 10/9 Vaccines and Related Biological Products Advisory Committee meeting to make recommendations on the strain selection for influenza...

medical-devices
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Capsida Pauses Gene Therapy Trial After Death

Capsida Biotherapeutics stops enrollment in its SYNRGY clinical trial that is evaluating gene therapy CAP-002 for treating STXBP1 developmental and ep...

medical-devices
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Guide on Biosimilar Formal Meeting Requsts

FDA releases a final guidance entitled Formal Meetings Between the FDA and Sponsors or Applicants of BsUFA Products.

medical-devices
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Sumitomo Pharma Gets Fast Track Status for Nuvisertib

FDA grants Sumitomo Pharma a fast-track designation for nuvisertib (TP-3654) for treating patients with intermediate or high-risk myelofibrosis.

Biologics

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medical-devices
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Interchangeability Status on Celltrion Biosimilars

FDA grants interchangeability designations to Celltrion’s denosumab biosimilars, Stoboclo (denosumab-bmwo) and Osenvelt (denosumab-bmwo), making them ...

medical-devices
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J&J Seeks Stelara Expanded Use

Johnson & Johnson files a supplemental BLA seeking to expand the use of its biologic therapy Stelara (ustekinumab) to treat children aged two years an...

medical-devices
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Clinical Hold on 2 Intellia Gene Therapy Trials

FDA issues a clinical hold on Intellia Therapeutics’ MAGNITUDE and MAGNITUDE-2 Phase 3 trials for nexiguran ziclumeran after the company disclosed Gra...

medical-devices
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FDA Aims to Cut Comparative Efficacy Studies for Biosimilars

FDA proposes a major shift in how biosimilars are evaluated, signaling that many products may no longer need traditional comparative clinical efficacy...

FDA General

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medical-devices
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Sen. Banks Presses FDA to Ramp Up Foreign Inspections

Sen. Jim Banks (R-IN) urges FDA to step up inspections of pharmaceutical manufacturing facilities abroad, citing persistent quality lapses and lagging...

medical-devices
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GOP Senators Call on FDA to Restrict Generic Mifepristone

Fifty-one Republican senators urge FDA to restrict access to abortion pills following the agency’s recent approval of a new generic version of mifepri...

medical-devices
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Public Rating of FDA, Others Dropping

A Gallup Poll shows that Americans’ ratings of FDA and many other federal agencies have dropped in the last year to at or near their lowest point.

medical-devices
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Makary Outlines ‘Mission Critical’ Ops Under Shutdown

FDA commissioner Marty Makary tells employees affected by the government shutdown that the agency will continue mission-critical activities necessary ...

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Federal Register

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PDUFA Public Meeting for User Fee Reauthorization

Federal Register notice: FDA announces a 7/14 public meeting to discuss proposed recommendations for...

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Generic Drug Fee Program Reauthorization Meeting

Federal Register notice: FDA hosts a 7/11 public meeting on the reauthorization of the Generic Drug ...

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FDA Withdraws and Reissues 2 Guidances

FDA says it is withdrawing two recent final guidances on cell- and tissue-based products and reissui...

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CDER Continues Quality Management Program

Federal Register notice: FDA seeks drug manufacturing establishments to participate in the second ye...

Human Drugs

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Lilly Hopeful Obesity Pill Accepted in Voucher Program

Eli Lilly says its investigational weight-loss pill met most criteria for FDA’s new national priorit...

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FDA to Unveil Faster Pathway for Gene-Editing Therapies

CBER director Vinay Prasad says FDA is preparing to introduce a new, accelerated pathway for approvi...

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FDA Moves to Restrict Unapproved Fluoride Drugs

FDA announces new actions aimed at protecting children from unapproved ingestible fluoride prescript...

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Senators Want Foreign Generic Drug Info

Leaders of the Senate Special Committee on Aging ask executives of three group purchasing organizati...

Marketing

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Create ‘Drug Facts’ Box for DTC Ads: Column

Two academic researchers urge FDA to require a Drug Facts box in direct-to-consumer ads so consumers...

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WLF Wants End to FDA TV Ad ‘Crackdown’

The Washington Legal Foundation calls on the FDA to stop its broad crackdown on drug TV advertising,...

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40 DTC Untitled Letters Posted by FDA

FDA releases 40 cease and desist (untitled) letters to drug companies that the agency said were issu...

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Makary JAMA Piece Explains DTC Ad Crackdown

FDA commissioner Martin Makary pens an online JAMA Viewpoint to explain why the agency is moving to ...

Medical Devices

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Safety Data Update on Hintermann Ankle Device

FDA issues an updated safety communication confirming long-term post-approval data showing that the ...

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FDA Clears Tosoh’s Next-Generation HbA1c Analyzer

FDA clears a Tosoh Bioscience 510(k) for its next-generation Automated Glycohemoglobin Analyzer for ...

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2 QSR Violations at Qinjiang Kingphar Medical

FDA warns China’s Qinjiang Kingphar Medical Material Co. about Quality System violations in its prod...

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Multiple Violations Seen in Contec Medical Inspection

FDA warns China’s Contec Medical Systems about Quality System and Medical Device Reporting violation...