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FDA grants Bayer a priority review for its supplemental NDA for Hyrnuo (sevabertinib) as a first-line treatment for patients with HER2-mutant non-small cell lung cancer.

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In an opern letter to president Trump, rare disease advocates urge him to push FDA to accelerate approvals for treatments targeting fatal genetic disorders, arguing that regulatory delays are costing patients valuable time.

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Bayer sNDA for Hyrnuo Granted Priority Review

FDA grants Bayer a priority review for its supplemental NDA for Hyrnuo (sevabertinib) as a first-line treatment for patients with HER2-mutant non-small cell lung cancer.

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Open Letter to Trump Urges FDA Push on Rare Diseases

In an opern letter to president Trump, rare disease advocates urge him to push FDA to accelerate approvals for treatments targeting fatal genetic disorders, arguing that regulatory delays are costing patients valuable time.

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Regeneron Melanoma Trial Misses Primary Endpoint

Regeneron Pharmaceuticals says its Phase 3 trial evaluating the experimental immunotherapy combination of fianlimab and cemiplimab in advanced melanoma failed to meet its primary endpoint.

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Merck’s Sac-TMT Get Win in Endometrial Cancer

Merck reports that its Phase 3 TroFuse-005 trial evaluating the investigational antibody-drug conjugate sacituzumab tirumotecan met its primary endpoints in certain patients with advanced or recurrent endometrial cancer.

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Animal Drugs

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medical-devices
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Open Letter to Trump Urges FDA Push on Rare Diseases

In an opern letter to president Trump, rare disease advocates urge him to push FDA to accelerate approvals for treatments targeting fatal genetic diso...

medical-devices
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FDA Guide on Developing Drugs for Pulmonary Tuberculosis

FDA posts updated guidance outlining how drugmakers should design clinical development programs for new tuberculosis treatments, emphasizing the need ...

medical-devices
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White House Reportedly Moves to Oust Commissioner Makary

Several media outlets report that President Trump has signed off on a plan to remove FDA commissioner Marty Makary from his post.

medical-devices
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Atara says FDA outlined potential path for Cell Therapy Resubmission

Atara Biotherapeutics says it and partner Pierre Fabre Pharmaceuticals have received feedback from FDA outlining a potential path toward resubmitting ...

Biologics

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medical-devices
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Democratic Health Leaders Question FDA Study Suppression

Democratic leaders on the House Energy and Commerce Committee accuse HHS secretary Robert F. Kennedy Jr. of suppressing scientific research supporting...

medical-devices
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Partner Therapeutics Wins Approval for Bile Duct Cancer Therapy

FDA approves a Partner Therapeutics BLA for Bizengri (zenocutuzumab-zbco) for adults with advanced, unresectable or metastatic cholangiocarcinoma harb...

medical-devices
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CBER Acting Head Highlights Regulatory Flexibility, AI and Rare Disease Priorities

CBER acting director Katherine Szarama discusses an expansive vision for the biologics center during remarks at the Food and Drug Law Institute’s annu...

medical-devices
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Scrutiny of Gene Therapy Evidence Intensifies After Recent Setbacks

An opinion article notes that recent FDA regulatory decisions are leading to a sharper focus on the evidentiary standards underpinning cell and gene t...

FDA General

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medical-devices
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Health Affairs Commentary Says Makary Left FDA ‘Weaker’

Two prominent drug-policy scholars sharply criticize former FDA commissioner Marty Makary in a Health Affairs commentary, arguing that his tenure weak...

medical-devices
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FDA May be OK Under Loper Bright: Article

University of Missouri law professor Erika Lietzan says FDA may not suffer as much under the Supreme Court’s Loper Bright decision as policy analysts ...

medical-devices
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Despite Makary Leaving, Industry Could Feel Pressure: Analysis

Analysts and investors interviewed by Reuters see a short-term positive reaction to the departure of Marty Makary, but caution that a prolonged leader...

medical-devices
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Inspection Pilot May be Permanent as FDA Expands AI-Driven Oversight

A King & Spalding legal analysis examines FDA’s newly announced pilot program for one-day inspectional assessments, suggesting it may signal a long-te...

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Federal Register

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FDA Delays Review Action on Alzheimer’s Drug

FDA delays by three months its decision on Eisai and Biogen's subcutaneous starting-dose formulation...

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Alnylam Pharma’s Web Promo is Misleading: FDA

FDA sends an untitled letter to Alnylam Pharmaceuticals, citing misleading promotional claims on a c...

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PhRMA Urges Changes to FDA’s ‘Plausible Mechanism’ Guidance

PhRMA urges FDA to broaden and clarify its draft guidance on individualized therapies, warning that ...

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Purdue Sentencing Sets $5.3 Billion in Criminal Penalties

A federal court sentences Purdue Pharma to pay more than $5 billion in criminal penalties for its ro...

Human Drugs

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Bayer sNDA for Hyrnuo Granted Priority Review

FDA grants Bayer a priority review for its supplemental NDA for Hyrnuo (sevabertinib) as a first-lin...

motusgi
Read More
Regeneron Melanoma Trial Misses Primary Endpoint

Regeneron Pharmaceuticals says its Phase 3 trial evaluating the experimental immunotherapy combinati...

motusgi
Read More
Merck’s Sac-TMT Get Win in Endometrial Cancer

Merck reports that its Phase 3 TroFuse-005 trial evaluating the investigational antibody-drug conjug...

motusgi
Read More
FDA Guide Reshaping Off-Label Communications: Legal Analysis

A legal analysis reviews how an FDA guidance issued last year is reshaping how pharmaceutical and me...

Marketing

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DTC Crackdown Unfazed at Post-Makary FDA: Expert

DTC Perspectives CEO Bob Ehrlich says the sudden departure of former FDA commissioner Marty Makary i...

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Brukinsa TV Ad ‘False or Misleading’: OPDP

A CDER Office of Prescription Drug Promotion Notice of Violation cites a misleading BeOne Medicine T...

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Advertising Experts Critique FDA’s Increasing Enforcement

Pharmaceutical advertising experts react to FDA’s dramatically altered enforcement approach toward p...

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Nubeqa TV Ad, Video Misleading: FDA

The CDER Office of Prescription Drug Promotion cautions Bayer that a video and TV ad for its Nubeqa ...

Medical Devices

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Early Alert on Drager Anesthesia Workstations

FDA issues an early alert warning healthcare providers about a potentially high-risk problem involvi...

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Petition Urges Actions Against Weight Loss Device

A citizen petition urges FDA to take enforcement action against the BariClip, an implantable bariatr...

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Boston Scientific Device Correction on Certain Pacemakers

Boston Scientific begins a Class 1 recall (device correction) involving certain pacemakers and cardi...

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Guidance On Patient-Matched Guides for Orthopedic Implants

FDA posts a new guidance detailing how manufacturers should design and submit regulatory application...