Federal Register Direct final rule: FDA is confirming the effective date of 4/23, for the direct final rule that appeared in the 12/7/06 Federal Register amending the regulation to remove beclomethasone, dexamethasone, fluticasone, bitolterol, salmeterol, ergotamine tartrate, and ipratropium bromide, used in oral pressurized metered-dose inhalers, from the list of essential uses of ozone-depleting substances. None of these products is currently being marketed. To view this direct final rule, click here.